GDNF Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-499-0.002mg | 0.002mg | £300.00 |
Quantity:
| PSI-40-499-0.01mg | 0.01mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized GDNF recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted GDNF is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposin
Documents
Further Information
Additional Names:
ATF1, ATF2, HSCR3, HFB1-GDNF, Glial cell line-derived neurotrophic factor, Astrocyte-derived trophic factor, hGDNF
Background:
GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRalpha (alpha1-alpha4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer, of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which (Cys 101) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
Biological Activity:
Determined by a cell proliferation assay using SH-SY5Y cells. The expected ED50 for this effect is 1.0-10.0 ng/ml.
NCBI Gene ID #:
2668
NCBI Official Name:
glial cell derived neurotrophic factor
NCBI Official Symbol:
GDNF
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000505.1
Protein GI Number:
4503975
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P39905