M-CSF Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-288-0.002mg | 0.002mg | £300.00 |
Quantity:
| PSI-40-288-0.01mg | 0.01mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized M-CSF recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted M-CSF is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, expos
Documents
Further Information
Additional Names:
MCSF, CSF-1, Macrophage colony-stimulating factor 1, Lanimostim
Background:
M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant human M-CSF is a 36.8 kDa homodimeric protein containing two 159 amino acid polypeptide subunits.
Biological Activity:
The ED50 was determined by the dose - dependent stimulation of the proliferation of murine M - NSF - 60 cells ≤ 5 ng/mL, corresponding to a specific activity of ≥ 2 x 105 units/mg.
NCBI Gene ID #:
1435
NCBI Official Name:
colony stimulating factor 1 (macrophage)
NCBI Official Symbol:
CSF1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000748.3
Protein GI Number:
27262661
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P09603