Oncostatin M Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-284-0.002mg | 0.002mg | £300.00 |
Quantity:
| PSI-40-284-0.01mg | 0.01mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Oncostatin M recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Oncostatin M is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any
Documents
Further Information
Additional Names:
Oncostatin-M, OSM
Background:
Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activate T cells, monocytes and Kaposi?s sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi?s sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. The human OSM gene encodes for a 252 amino acid polypeptide, containing 25 amino acid signal sequence for secretion and a 227 precursor protein. Proteolytic processing of this precursor removes an 18 amino acid C-terminal peptide and generates the mature OSM form. Recombinant human Oncostatin M is a 23.9 kDa protein, containing 209 amino acid residues.
Biological Activity:
The ED50 was determined by the dose - dependent stimulation of the proliferation of human TF - 1 cells is ≤ 2.0 ng/mL, corresponding to a specific activity of ≥ 5 x 105 units/mg.
NCBI Gene ID #:
5008
NCBI Official Name:
oncostatin M
NCBI Official Symbol:
OSM
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_065391.1
Protein GI Number:
10092621
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P13725