PAI-1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-126-0.002mg | 0.002mg | £300.00 |
Quantity:
| PSI-40-126-0.01mg | 0.01mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized PAI-1 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted PAI-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, expos
Documents
Further Information
Additional Names:
PAI, PAI1, PAI-1, PLANH1, Plasminogen activator inhibitor 1, Endothelial plasminogen activator inhibitor, PAI
Background:
Plasminogen Activator Inhibitor-1 (PAI-1, Serpin E1) is a member of the serpin family of serine protease inhibitors, and is the primary inhibitor of urokinase and tissue plasminogen activator (tPA). PAI-1 is expressed predominantly in adipose, liver and vascular tissues, and is also produced by certain tumor cells. Elevated levels of PAI-1 are associated with obesity, diabetes and cardiovascular disease, and increased production of PAI-1 is induced by various obesity related factors such as TNFα, glucose, insulin, and very-low-density lipoprotein. The obesity related elevation of PAI-1 levels along with the consequential deficiency in plasminogen activators can lead directly to increased risk of thrombosis and other coronary diseases. Accordingly, PAI-1 has been implicated as an important molecular link between obesity and coronary disease. PAI-1 can also specifically bind vitronectin (VTN) to form a stable active complex with an increased circulatory half life relative to free PAI-1. Recombinant human PAI-1 is a 42.7 kDa protein containing 379 amino acid residues.
Biological Activity:
Determined by its inhibitory effect against single chain tPA induced cleavage of a chromogenic substrate in Imidazole Buffer at 37˚C. Half maximal inhibition against 1.0 μg/mL of single chain tPA was obtained at a concentration of 2.0 μg/mL.
NCBI Gene ID #:
5054
NCBI Official Name:
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
NCBI Official Symbol:
SERPINE1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000593.1
Protein GI Number:
10835159
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P05121