TIMP-2 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-142-0.002mg | 0.002mg | £300.00 |
Quantity:
| PSI-40-142-0.01mg | 0.01mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized TIMP-2 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TIMP-2 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exp
Documents
Further Information
Additional Names:
DDC8, CSC-21K, Metalloproteinase inhibitor 2, TIMP-2
Background:
TIMP-2 is an extracellular inhibitor of MMPs including MMP1, 2, 3, 7, 8, 9, 10, 12, 13, 14, 15, 16 and 19. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP-2 can also act through an MMP-independent mechanism inhibiting endothelial cell proliferation in vitro and demonstrates anti-angiogenic activities in vivo. Recombinant human TIMP-2 is a 21.8 kDa protein containing 194 amino acid residues.
Biological Activity:
TIMP - 2 activity was measured by its ability to inhibit human MMP - 1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP - 2 concentration of approximately 0.5 μg/mL, when using an MMP - 1 concentration of 1.6 μg/mL.
NCBI Gene ID #:
7077
NCBI Official Name:
TIMP metallopeptidase inhibitor 2
NCBI Official Symbol:
TIMP2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_003246.1
Protein GI Number:
4507511
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P16035