TSLP Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-294-0.002mg | 0.002mg | £300.00 |
Quantity:
| PSI-40-294-0.01mg | 0.01mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized TSLP recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TSLP is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposin
Documents
Further Information
Additional Names:
Thymic stromal lymphopoietin
Background:
TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (DCs). TSLP activated DCs primed na?ve T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFα) while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation. Recombinant human TSLP is a 15.0 kDa protein consisting of 132 amino acid residues.
NCBI Gene ID #:
85480
NCBI Official Name:
thymic stromal lymphopoietin
NCBI Official Symbol:
TSLP
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_149024.1
Protein GI Number:
14719428
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q969D9