BD-2 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-131-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-131-0.02mg | 0.02mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized BD-2 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted BD-2 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposin
Documents
Further Information
Additional Names:
BD-2, SAP1, DEFB2, DEFB4, HBD-2, DEFB-2, DEFB102, DEFB4B, Beta-defensin 4A, Beta-defensin 2, BD-2
Background:
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. Recombinant Human BD-2 is a 4.3 kDa protein containing 41 amino acid residues.
Biological Activity:
Determined by its ability to chemoattract immature human dendritic cells using a concentration of 10.0 - 100.0 ng/mL.
NCBI Gene ID #:
1673
NCBI Official Name:
defensin, beta 4A
NCBI Official Symbol:
DEFB4A
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_004933.1
Protein GI Number:
4826692
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
O15263