NP-1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-130-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-130-0.02mg | 0.02mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized NP-1 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted NP-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposin
Documents
Further Information
Additional Names:
HP1, MRS, DEF1, HP-1, DEFA2, HNP-1, DEFA1B, Neutrophil defensin 1, Defensin, alpha 1
Background:
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins which include NP-1, NP-2 and NP-3, are distinguished from the β-defensins by the pairing of their three disulfide bonds. In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells. NP-1 is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide. NP-1 contains a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant human NP-1 is a 3.4 kDa protein containing 30 amino acid residues.
Biological Activity:
Determined by its ability to chemoattract immature dendritic cells using a concentration of 1.0 - 10.0 ng/mL.
NCBI Gene ID #:
1667
NCBI Official Name:
defensin, alpha 1
NCBI Official Symbol:
DEFA1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_004075.1
Protein GI Number:
4758146
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P59665