TACI Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-308-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-308-0.02mg | 0.02mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized TACI recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TACI is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposin
Documents
Further Information
Additional Names:
CVID, RYZN, TACI, CD267, CVID2, TNFRSF14B, Tumor necrosis factor receptor superfamily member 13B, Transmembrane activator and CAML interactor
Background:
TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and BAFF and can stimulate the activation of transcription factors; NF-kappaB, AP-1, and mediates calcineurin dependent activation of NF-AT (nuclear-factor of activated T cells). TACI also plays a key role in the stimulation of B and T cell function. Soluble TACI inhibits APRIL-stimulated proliferation of primary B-cells by blocking the binding of APRIL to the membrane anchored TACI receptor. Recombinant human TACI is a soluble 160 amino acid polypeptide (17.8 kDa) comprising the TNFR homologous cysteine rich extracellular domain of the TACI protein.
Biological Activity:
Biological activity was determined by its ability to block human BAFF induced T2B cell survival using a concentration range of 1.0 - 3.0 μg/mL.
NCBI Gene ID #:
23495
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 13B
NCBI Official Symbol:
TNFRSF13B
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_036584.1
Protein GI Number:
6912694
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
O14836