TNF beta Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-275-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-275-0.02mg | 0.02mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized TNF beta recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TNF beta is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein,
Documents
Further Information
Additional Names:
LT, TNFB, TNFSF1, Lymphotoxin-alpha, TNF-beta, LT-alpha
Background:
TNF-β is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-β is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-α, TNF-β is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-β is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-β, which effectively anchors the TNF-β to the cell surface. TNF-β is cytotoxic to a wide range of tumor cells. Recombinant human TNF-β is a secreted 171 amino acid protein (18.6 kDa) which forms an active non-disulfide linked homotrimer structure in solution.
Biological Activity:
The ED50 was determined by the cytolysis of murine L929 cells in the presence of Actinomycin - D is ≤ 0.05 ng/mL, corresponding to a specific activity of ≥ 2 x 107 units/mg.
NCBI Gene ID #:
4049
NCBI Official Name:
lymphotoxin alpha
NCBI Official Symbol:
LTA
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000586.2
Protein GI Number:
6806893
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P01374