Trefoil Factor 3 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-293-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-293-0.02mg | 0.02mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Trefoil Factor 3 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Trefoil Factor 3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As w
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Further Information
Additional Names:
ITF, P1B, TFI, ITF, Trefoil factor 3, Intestinal trefoil factor, hITF
Background:
The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are secreted in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF-3 is expressed by goblet cells and in the uterus, and has also been shown to express in certain cancers, including colorectal, hepatocellular, and in biliary tumors. TFF3 may be useful as a molecular marker for certain types of cancer, but its role, if any, in tumorigenesis is unknown. TFF3 also promotes airway epithelial cell migration and differentiation. Recombinant human TFF3 is a 13.2 kDa homodimeric protein consisting of two 59 amino acid chains, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.
Biological Activity:
Biological activity was determined by its ability to chemoattract human MCF - 7 cells using a concentration range of 1.0 - 10.0 μg/mL.
NCBI Gene ID #:
7033
NCBI Official Name:
trefoil factor 3 (intestinal)
NCBI Official Symbol:
TFF3
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_003217.3
Protein GI Number:
281485608
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q07654