Epiregulin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-149-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-149-0.025mg | 0.025mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Epiregulin recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Epiregulin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any prot
Documents
Further Information
Additional Names:
ER, Proepiregulin, EPR
Background:
Epiregulin is an EGF related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes and in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence. Recombinant human Epiregulin is a 5.6 kDa monomeric protein, containing 50 amino residues, which corresponds to the mature secreted Epiregulin sequence.
Biological Activity:
The ED50 was determined by its ability to inhibit IGF - II induced proliferation of MCF - 7 is ≤ 0.3 μg/mL in the presence of 15 ng/mL of human IGF - II.
NCBI Gene ID #:
2069
NCBI Official Name:
epiregulin
NCBI Official Symbol:
EREG
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001423.1
Protein GI Number:
4557567
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
O14944