IGF-BP5 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-150-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-150-0.025mg | 0.025mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized IGF-BP5 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted IGF-BP5 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, e
Documents
Further Information
Additional Names:
IBP5, IBP5, Insulin-like growth factor-binding protein 5, IBP-5
Background:
IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP5 is a 28.6 kDa cysteine-rich secreted protein produced by vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGFBP-5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP-5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development. Recombinant human IGF-BP5 is a 28.6 kDa protein consisting of 253 amino acid residues.
Biological Activity:
The ED50 was determined by its ability to inhibit IGF - II induced proliferation of MCF - 7 is ≤ 0.3 μg/mL in the presence of 15 ng/mL of human IGF - II.
NCBI Gene ID #:
3488
NCBI Official Name:
insulin-like growth factor binding protein 5
NCBI Official Symbol:
IGFBP5
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000590.1
Protein GI Number:
10834982
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P24593