TWEAK Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-298-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-298-0.025mg | 0.025mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized TWEAK recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TWEAK is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, expos
Documents
Further Information
Additional Names:
APO3L, DR3LG, TWEAK, APO3L, UNQ181/PRO207, Tumor necrosis factor ligand superfamily member 12, APO3 ligand
Background:
TWEAK belongs to the TNF family of ligands and signals through TWEAKR also known as TNFRSF12A. TWEAK is expressed in a variety of tissues, including the adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. TWEAK has the ability to induce NFkB activation and chemokine secretion, and to exert an apoptotic activity in certain cells, such as HT-29 human adenocarcinoma cells when cultured in the presence of IFN-γ. TWEAK also promotes proliferation and migration of endothelial cells. Recombinant human TWEAK is a soluble 17.0 kDa polypeptide (154 amino acid residues) comprising the TNF homologous region of TWEAK and is generated by proteolytic processing of the full length membrane anchored TWEAK protein.
Biological Activity:
Assay 1: The ED50 was determined by the dose - dependent stimulation of IL - 8 production by Human PBMC is less than 10 ng/mL.
Assay 2: TWEAK weakly induces the death of HT29 cells when cultured in the presence of IFN - γ. The ED50 for this effect is between 30 - 45 ng/mL.
Assay 2: TWEAK weakly induces the death of HT29 cells when cultured in the presence of IFN - γ. The ED50 for this effect is between 30 - 45 ng/mL.
NCBI Gene ID #:
8742
NCBI Official Name:
tumor necrosis factor (ligand) superfamily, member 12
NCBI Official Symbol:
TNFSF12
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_003800.1
Protein GI Number:
4507597
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
O43508