Amphiregulin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-546-0.01mg | 0.01mg | £300.00 |
Quantity:
| PSI-40-546-0.05mg | 0.05mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Amphiregulin recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Amphiregulin stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any pro
Documents
Further Information
Additional Names:
AR, SDGF, CRDGF, AREGB, Amphiregulin, Colorectum cell-derived growth factor, AR
Background:
Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-a receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin?s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant human Amphiregulin is a 11.3 kDa glycoprotein consisting of 98 amino acid residues.
Biological Activity:
Biological activity was determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/mL. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
NCBI Gene ID #:
374
NCBI Official Name:
amphiregulin
NCBI Official Symbol:
AREG
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001648.1
Protein GI Number:
4502199
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P15514