Galectin-3 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-329-0.01mg | 0.01mg | £300.00 |
Quantity:
| PSI-40-329-0.05mg | 0.05mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Galectin-3 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Galectin-3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any prot
Documents
Further Information
Additional Names:
L31, GAL3, MAC2, CBP35, GALBP, GALIG, LGALS2, Galectin-3, 35 kDa lectin, Gal-3
Background:
Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with beta-galactoside moieties. Galectin-3 regulates a number of biological processes, including embryogenesis, inflammatory responses, cell progression and metastasis. Galectin-3 is normally expressed in epithelia of a variety of tissues, including colon and endometrium, and in various inflammatory cells, including macrophages. Galectin-3 can function intracellularly, in controlling cell cycle and preventing T-cell apoptosis, and also extracellularly, in activating various cells, including monocytes/macrophages, mast cells, neutrophils, and lymphocytes. Expression of Galectin-3 is affected by neoplastic transformation, being up-regulated in certain types of lymphomas, and in thyroid and hepatic carcinomas. Conversely, it is down-regulated in other cancers, such as colon, breast, ovarian, and uterine. Recombinant human Galectin-3 is a globular 26.0kDa protein containing 250 amino acid residues, but no disulfide bonds.
Biological Activity:
Biological activity was determined by its ability to chemoattract human blood monocytes. Chemotactic activity was observed at a concentration of 2.5 μg/mL with a peak response obtained at 250 μg/mL.
NCBI Gene ID #:
3958
NCBI Official Name:
lectin, galactoside-binding, soluble, 3
NCBI Official Symbol:
LGALS3
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_002297.2
Protein GI Number:
115430223
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P17931