Osteoprotegerin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-323-0.01mg | 0.01mg | £300.00 |
Quantity:
| PSI-40-323-0.05mg | 0.05mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Osteoprotegerin recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Osteoprotegerin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As wit
Documents
Further Information
Additional Names:
OPG, TR1, OCIF, OPG, Tumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor
Background:
Osteoprotegerin (OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. OPG is expressed in a wide variety of tissues including adult heart, lung, kidney, liver, spleen, prostate, lymph node and bone marrow. OPG is secreted both as a monomeric and a dimeric protein. Its primary structure consists of seven distinct domains, four of which corresponds to the extracellular cysteine-rich domains of TNFR proteins and constitutes the soluble OPG. Recombinant human OPG is a soluble 20.0 kDa protein containing 174 amino acid residues.
Biological Activity:
Determined by its ability to inhibit TRAIL-induced apoptosis of LN-18 glioblastoma cells.
NCBI Gene ID #:
4982
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 11b
NCBI Official Symbol:
TNFRSF11B
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_002537.3
Protein GI Number:
148743793
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
O00300