Activin-A Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-544-0.01mg | 0.01mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Activin-A recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Activin-A stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein,
Documents
Further Information
Additional Names:
JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2, Mothers against decapentaplegic homolog 2, MAD homolog 2
Background:
Activin A is a TGF-β family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Recombinant human Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.
Biological Activity:
Biological activity was determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/mL, corresponding to a specific activity of ≥ 5 x 105 units/mg. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
NCBI Gene ID #:
4087
NCBI Official Name:
SMAD family member 2
NCBI Official Symbol:
SMAD2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001003652.1
Protein GI Number:
51173730
Purity:
Greater than 97% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q15796