Flt3-Ligand Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-590-0.01mg | 0.01mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Flt3-Ligand recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Flt3-Ligand is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any pr
Documents
Further Information
Additional Names:
FL, FLT3L, Fms-related tyrosine kinase 3 ligand, SL cytokine, Flt3 ligand
Background:
Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand exerts no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant human Flt3-Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues.
Biological Activity:
of BaF3 cells expressing FGF receptors using Cell Counting Kit-8 (CCK-8). The expected ED50 is < 0.5 ng/ml corresponding to a specific activity of > 2 x 106 units/mg.
NCBI Gene ID #:
2323
NCBI Official Name:
fms-related tyrosine kinase 3 ligand
NCBI Official Symbol:
FLT3LG
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001191431.1
Protein GI Number:
325197197
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P49771