IGF-II Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-596-0.05mg | 0.05mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized IGF-II recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted IGF-II is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exp
Documents
Further Information
Additional Names:
IGF-II, PP9974, C11orf43, Insulin-like growth factor II, Somatomedin-A, IGF-II
Background:
The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.
Biological Activity:
Determined by its ability to stimulate the proliferation of mouse FDC-P1 cells. The expected ED50 is = 2.0 ng/mL, corresponding to a specific activity of = 5 x 105 units/mg.
NCBI Gene ID #:
3481
NCBI Official Name:
insulin-like growth factor 2 (somatomedin A)
NCBI Official Symbol:
IGF2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000603.1
Protein GI Number:
4504609
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P01344