TGF-a Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-573-0.1mg | 0.1mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized TGF-a recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TGF-a stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing
Documents
Further Information
Additional Names:
TFGA, Protransforming growth factor alpha, EGF-like TGF, TGF-alpha
Background:
TGF-α is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-α induces transformation anchorage independence in cultured cells. Human, murine and rat TGF-α are cross-species reactive. Recombinant human TGF-α is a 50 amino acid polypeptide (5.5 kDa) which shares approximately 40% sequence homology with EGF, including 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds.
Biological Activity:
Biological activity was determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 is ≤ 0.2 ng/mL, corresponding to a specific activity of ≥> 5 x 106 units/mg. Endotoxin level is less than 0.1 ng per μg of TGF-α (1EU/μg).
NCBI Gene ID #:
7039
NCBI Official Name:
transforming growth factor, alpha
NCBI Official Symbol:
TGFA
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001093161.1
Protein GI Number:
153791414
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P01135