sDLL-4 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-235-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-235-0.025mg | 0.025mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized sDLL-4 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted sDLL-4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exp
Documents
Further Information
Additional Names:
hdelta2, Delta-like protein 4, Drosophila Delta homolog 4, Delta4
Background:
Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL4 gene in mice resulted in severe vascular defects and death before birth. Up-regulation of DLL4 expression has been implicated in the vascular development of certain tumors. Recombinant human sDLL4 is a 54.0 kDa glycoprotein containing 498 amino-acid residues.
Biological Activity:
The sDLL - 4, when immobilized at concentrations >1.5 μg/mL will inhibit myogenesis in C2C12 cells.
NCBI Gene ID #:
54567
NCBI Official Name:
delta-like 4 (Drosophila)
NCBI Official Symbol:
DLL4
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_061947.1
Protein GI Number:
9506545
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q9NR61