Adiponectin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-328-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-328-0.025mg | 0.025mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Adiponectin recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Adiponectin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any pr
Documents
Further Information
Additional Names:
ACDC, ADPN, APM1, APM-1, GBP28, ACRP30, ADIPQTL1, ACDC, Adiponectin, 30 kDa adipocyte complement-related protein
Background:
Adiponectin is an adipose-derived secreted protein containing 226 amino acid residues. It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-α and class A scavenger receptor in macrophages). Recombinant adiponectin is a multimeric glycoprotein containing amino acids Glu-19 to Asn-244 of the adiponectin precursor protein fused to an N-terminal histidine tag. Monomeric glycosylated adiponectin migrates at an apparent molecular weight of approximately 25.9 kDa by SDS PAGE analysis under reducing conditions.
Biological Activity:
Biological activity was determined by a cytotoxic assay using M1 cells. The ED50 for this effect is 3.0 - 6.0 μg/mL.
NCBI Gene ID #:
9370
NCBI Official Name:
adiponectin, C1Q and collagen domain containing
NCBI Official Symbol:
ADIPOQ
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001171271.1
Protein GI Number:
295317372
Purity:
Greater than 97% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
High-5 Insect cells
Swissprot #:
Q15848