HVEM-Fc Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-316-0.02mg | 0.02mg | £300.00 |
Quantity:
| PSI-40-316-0.1mg | 0.1mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized HVEM-Fc recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted HVEM-Fc is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, e
Documents
Further Information
Additional Names:
TR2, ATAR, HVEA, HVEM, CD270, LIGHTR, UNQ329/PRO509, Tumor necrosis factor receptor superfamily member 14, Herpes virus entry mediator A, Herpesvirus entry mediator A
Background:
HVEM belongs to the TNF Receptor superfamily of transmembrane proteins and plays a role in the activation of T-cells and other lymphocytes. It is expressed in various cells and tissues including spleen, thymus, lung, macrophages, and T-cells. HVEM activation induces a signaling cascade which results in induction of transcription factors NF-kappaB and AP-1. LIGHT (TNFSF14) and TNF-beta (TNFSF1) function as the ligands for HVEM, which can also bind specifically to herpes simplex virus glycoprotein D. Soluble HVEM, which tends to form disulfide-linked heterodimeric complexes in solution, can act as a "receptor decoy? resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-beta. Recombinant human HVEM-Fc Chimera is a 376 amino acid fusion protein containing an N-terminal domain corresponding to the extracellular region of HVEM and a C-terminal domain corresponding to residues 102 to 330 of human IgG1.
Biological Activity:
Biological activity was determined by its ability to neutralize 0.25 ng/mL of hTNFB induced cytotoxicity on murine L929 cells. The expected ED50 for this effect is 1.3 - 1.9 μg/mL of HVEM - Fc.
NCBI Gene ID #:
8764
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 14
NCBI Official Symbol:
TNFRSF14
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_003811.2
Protein GI Number:
23200041
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
High-5 Insect cells
Swissprot #:
Q92956