IGF-BP6 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-320-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-320-0.02mg | 0.02mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized IGF-BP6 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted IGF-BP6 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, e
Documents
Further Information
Additional Names:
IBP6, IBP6, Insulin-like growth factor-binding protein 6, IBP-6
Background:
IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP6 is produced by bone cells and is the major IGF-BP present in cerebrospinal fluid, and specifically inhibits IGF-II actions. IGF-BP6 has been shown to inhibit IGF-II-dependent cancers such as neuroblastoma, colon cancer and rhabdomyosarcoma. Recombinant human IGF-BP6 has a calculated mass of 22.6 kDa and consists of 213 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain. IGF-BP6 migrates at an apparent molecular weight of approximately 23.0-30.0 kDa by SDS-PAGE analysis under non-reducing conditions.
Biological Activity:
Biological activity was determined by its ability to inhibit IGF - II induced proliferation of human MCF - 7 cells. The expected ED50 for this effect is 0.1 - 0.4 μg/mL.
NCBI Gene ID #:
3489
NCBI Official Name:
insulin-like growth factor binding protein 6
NCBI Official Symbol:
IGFBP6
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_002169.1
Protein GI Number:
11321593
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Swissprot #:
P24592