Granzyme B Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-125-0.002mg | 0.002mg | £300.00 |
Quantity:
| PSI-40-125-0.01mg | 0.01mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Storage:
The lyophilized Granzyme B recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Granzyme B is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any prot
Documents
Further Information
Additional Names:
GZB, CCP1, Ctla1, Ctla-1, AI553453, CCP-1/C11, CTLA-1
Background:
Granzyme B is a cysteine protease found in the cytoplasmic granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme B is required for the induction of target cell lysis, which occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms. Proteolytic cleavage of substrates by Granzyme B takes place primarily after aspartic acid residues. Recombinant murine Granzyme B is a glycosylated 227 amino acid protein, comprising the mature active portion of the murine Granzyme B precursor. The apparent molecular weight is 28.9 kDa by mass spectrometry.
Biological Activity:
Determined by its ability to cleave a synthetic chromogentic Granzyme B substrate. The expected specific activity, when using the Ac - IEPD - pNA substrate at 25˚C, is greater than 750 nM/min per μg of enzyme.
NCBI Gene ID #:
14939
NCBI Official Name:
granzyme B
NCBI Official Symbol:
Gzmb
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Protein Accession #:
NP_038570.1
Protein GI Number:
7305123
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
Baculovirus
Swissprot #:
P04187