IL-6 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-112-0.002mg | 0.002mg | £300.00 |
Quantity:
| PSI-40-112-0.01mg | 0.01mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Storage:
The lyophilized IL-6 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted IL-6 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposin
Documents
Further Information
Additional Names:
Il-6, Il-6, Interleukin-6, B-cell hybridoma growth factor, IL-6
Background:
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R alpha and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 187 amino acid residues.
Biological Activity:
The ED50 was determined by the dose - dependent stimulation of the proliferation of IL - 6 - dependent murine 7TD1 cells is < 0.02 ng/mL, corresponding to a specific activity of > 5 x 107 units/mg.
NCBI Gene ID #:
16193
NCBI Official Name:
interleukin 6
NCBI Official Symbol:
Il6
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Protein Accession #:
NP_112445.1
Protein GI Number:
13624311
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P08505