MIP-1 beta Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-358-0.002mg | 0.002mg | £300.00 |
Quantity:
| PSI-40-358-0.01mg | 0.01mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Storage:
The lyophilized MIP-1 beta recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted MIP-1 beta is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any prot
Documents
Further Information
Additional Names:
Act-2, Mip1b, Scya4, MIP-1B, AT744.1, C-C motif chemokine 4, Immune activation protein 2, ACT-2
Background:
Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant murine MIP-1 beta is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Biological Activity:
Biological activity was determined by its ability to chemoattract human monocytes using a concentration range of 20.0 - 100.0 ng/mL.
NCBI Gene ID #:
20303
NCBI Official Name:
chemokine (C-C motif) ligand 4
NCBI Official Symbol:
Ccl4
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Protein Accession #:
NP_038680.1
Protein GI Number:
7305459
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P14097