TNF alpha Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-446-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-446-0.02mg | 0.02mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Storage:
The lyophilized TNF alpha recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TNF alpha is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protei
Documents
Further Information
Additional Names:
DIF, Tnfa, TNF-a, TNFSF2, Tnfsf1a, TNFalpha, TNF-alpha, Tnfsf2, Tumor necrosis factor, Cachectin
Background:
TNF-alpha is a pleiotrophic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-alpha is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-alpha also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant murine TNF-alpha is a soluble 156 amino acid protein (17.3 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
Biological Activity:
The ED50 was determined by the cytolysis of murine L929 cells in the presence of actinomycin D is < 0.1 ng/mL, corresponding to a specific activity of > 1 x 107 units/mg.
NCBI Gene ID #:
21926
NCBI Official Name:
tumor necrosis factor
NCBI Official Symbol:
Tnf
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Protein Accession #:
NP_001265530.1
Protein GI Number:
518831589
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P06804