Neuropoietin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-442-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-442-0.025mg | 0.025mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Storage:
The lyophilized Neuropoietin recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Neuropoietin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any
Documents
Further Information
Additional Names:
NP, Gm494, Cardiotrophin-2, Neuropoietin, CT-2
Background:
Neuropoietin is a newly identified member of the IL-6 cytokine family. Members of this family, including IL-6, IL-11, oncostatin M, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, and CNTF, display a four-helix bundle structure, and signal through gp130-containing receptor complexes. Neuropoietin, which is predominantly expressed in neuroepithelia during embryonic life, acts through a receptor complex comprising CNTF receptor-a component, gp 130, and LIF receptor. Like CNTF, it promotes the survival of embryonic motor neurons and could increase the proliferation of neural precursor cells in the presence of EGF and FGF-2. Interestingly, the human Neuropoietin gene has evolved toward a pseudogene, suggesting that the alternative signaling via CNTF is an effective compensatory pathway. Recombinant murine Neuropoietin is a 19.8 kDa protein containing 183 amino acid residues.
Biological Activity:
The ED50 was determined by the dose - dependent stimulation of the proliferation of human TF - 1 cells is 0.5 - 0.8 μg/mL.
NCBI Gene ID #:
244218
NCBI Official Name:
cardiotrophin 2
NCBI Official Symbol:
Ctf2
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Protein Accession #:
NP_942155.1
Protein GI Number:
38524598
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P83714