IL-4 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-619-0.02mg | 0.02mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Storage:
The lyophilized IL-4 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted IL-4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposin
Documents
Further Information
Additional Names:
Il-4, BSF-1, Il-4, Interleukin-4, B-cell IgG differentiation factor, IL-4
Background:
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant murine IL-4 is a 13.5 kDa globular protein containing 120 amino acid residues.
Biological Activity:
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine HT-2 cells is =2.0 ng/mL, corresponding to a specific activity of = 5 x 105 units/mg
NCBI Gene ID #:
16189
NCBI Official Name:
interleukin 4
NCBI Official Symbol:
Il4
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Protein Accession #:
NP_067258.1
Protein GI Number:
10946584
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P07750