M-CSF Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-620-0.01mg | 0.01mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Storage:
The lyophilized M-CSF recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted M-CSF is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, expos
Documents
Further Information
Additional Names:
op, Csfm, MCSF, C87615, Macrophage colony-stimulating factor 1, CSF-1
Background:
M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4 kDa homodimeric protein containing two 156 amino acid polypeptide subunits.
Biological Activity:
Determined by its ability to stimulate the proliferation of murine M-NFS-60 cells. The expected ED50 is = 1.0 ng/mL, corresponding to a specific activity of =1 x 106 units/mg.
NCBI Gene ID #:
12977
NCBI Official Name:
colony stimulating factor 1 (macrophage)
NCBI Official Symbol:
Csf1
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Protein Accession #:
NP_001107001.1
Protein GI Number:
166064046
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P07141