CD16 Antibody [3G8] (FITC)
| Code | Size | Price |
|---|
| PSI-76-581-25tests | 25tests | £373.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: 3G8
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Documents
Further Information
Additional Names:
CD16, FCG3, CD16A, FCGR3, IGFR3, IMD20, FCR-10, FCRIII, FCGRIII, FCRIIIA, FCGR3A
Background:
The 3G8 monoclonal antibody specifically reacts with human CD16, the low affinity IgG receptor III (FC gamma RIII). CD16 is expressed on granulocytes, monocytes, macrophages, and NK cells and plays a role in NK activation and signal transduction. CD16 is expressed as either CD16a or CD16b. CD16a is a polypeptide-anchored transmembrane protein and CD16b is a glycosylphosphatidylinositol (GPI)-anchored protein that is expressed exclusively on neutrophils.
Background References:
- Leucocyte Typing VI: White Cell Differentiation Antigens: Proceedings of the Sixth International Workshop and Conference Held in Kobe, Japan, 10-14 November 1996. Garland Pub., 1998.
- Hayakawa, Y., Huntington, N. D., Nutt, S. L., Smyth, M. J. (2006). Functional subsets of mouse natural killer cells.Immunological reviews,214(1), 47-55.
- Tittarelli, A., Mendoza-Naranjo, A., Faras, M., Guerrero, I., Ihara, F., Wennerberg, E., ... Salazar-Onfray, F. (2014). Gap Junction Intercellular Communications Regulate NK Cell Activation and Modulate NK Cytotoxic Capacity.The Journal of Immunology,192(3), 1313-1319.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
FITC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
2214
NCBI Official Name:
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
NCBI Official Symbol:
FCGR3A
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Innate Immunity
SPECIFICITY:
The 3G8 monoclonal antibody specifically reacts with human CD16, the low affinity IgG receptor III (FC gamma RIII).
Swissprot #:
P08637
User NOte:
Optimal dilutions for each application to be determined by the researcher.