CD30 Antibody [Ber-H2] (FITC)
| Code | Size | Price |
|---|
| PSI-76-013-25tests | 25tests | £312.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: mouse IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: Ber-H2
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Documents
Further Information
Additional Names:
CD30, Ki-1, D1S166E, TNFRSF8
Background:
The Ber-H2 monoclonal antibody specifically reacts with human CD30, a 120kDA type I transmembrane glycoprotein of the tumor necrosis factor receptor superfamily (TNFR) also known as the Ki-1 antigen. CD30 can elicit signals leading to either activation or apoptosis through interaction with CD30 ligand (CD30L). It is expressed by a subset of extrafollicular activated B and T cells, lung macrophages, activated NK cells, lymphomas, and endothelial cells. It is highly expressed on Hodgkins and Reed-Sternberg cells.
Background References:
- Schwarting, R., Gerdes, J., Durkop, H., Falini, B., Pileri, S., Stein, H. (1989). BER-H2: a new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope.Blood,74(5), 1678-1689.
- Beljaards, R. C., Meijer, C. J., Scheffer, E., Toonstra, J., Van Vloten, W. A., Van Der Putte, S. C., ... Willemze, R. (1989). Prognostic significance of CD30 (Ki-1/Ber-H2) expression in primary cutaneous large-cell lymphomas of T-cell origin. A clinicopathologic and immunohistochemical study in 20 patients.The American journal of pathology,135(6), 1169.
- Horie, R., Watanabe, T. (1998, December). CD30: expression and function in health and disease. InSeminars in immunology(Vol. 10, No. 6, pp. 457-470). Academic Press.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
FITC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
943
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 8
NCBI Official Symbol:
TNFRSF8
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Apoptosis
SPECIFICITY:
The Ber-H2 monoclonal antibody specifically reacts with human CD30, a 120kDA type I transmembrane glycoprotein of the tumor necrosis factor receptor superfamily (TNFR) also known as the Ki-1 antigen.
Swissprot #:
P28908
User NOte:
Optimal dilutions for each application to be determined by the researcher.