CD45RO Antibody [UCHL1] (FITC)

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ProSci
Product Code: PSI-76-488
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-76-488-25tests25tests£307.00
Quantity:
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Overview

Host Type: Mouse
Antibody Isotype: Mouse IgG2a, kappa
Antibody Clonality: Monoclonal
Antibody Clone: UCHL1
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.

Images

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Human peripheral blood lymphocytes were stained with FITC UCHL1 with relevant isotype control in Red.
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Human peripheral blood lymphocytes were stained with FITC UCHL1 with relevant isotype control in Red.

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Further Information

Additional Names:
LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180, PTPRC
Background:
The UCHL1 monoclonal antibody specifically reacts with human CD45RO, a 180 kDa isoform of the leukocyte common antigen CD45. CD45RO is a transmembrane glycoprotein with tyrosine phosphatase activity and is expressed by majority of thymocytes, monocytes, granulocytes, and activated memory T lymphocytes. The subsets of peripheral T lymphocytes can be discriminated by using the CD45RO and CD45RA expressing cells.
Background References:
  • Knapp W(1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
  • Akbar, A. N., Terry, L., Timms, A., Beverley, P. C., Janossy, G. (1988). Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.The Journal of Immunology,140(7), 2171-2178.
  • Smith, S. H., Brown, M. H., Rowe, D., Callard, R. E., Beverley, P. C. (1986). Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1.Immunology,58(1), 63.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
FITC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
5788
NCBI Official Name:
protein tyrosine phosphatase, receptor type, C
NCBI Official Symbol:
PTPRC
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Immunology
SPECIFICITY:
The UCHL1 monoclonal antibody specifically reacts with human CD45RO, a 180 kDa isoform of the leukocyte common antigen CD45.
Swissprot #:
P08575
User NOte:
Optimal dilutions for each application to be determined by the researcher.