CD80 Antibody [2D10.4] (PE)
| Code | Size | Price |
|---|
| PSI-76-039-25tests | 25tests | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: 2D10.4
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Documents
Further Information
Additional Names:
B7, BB1, B7-1, B7.1, LAB7, CD28LG, CD28LG1, CD80
Background:
The 2D10.4 antibody reacts with human CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
Background References:
- Leucocyte Typing VI: White Cell Differentiation Antigens: Proceedings of the Sixth International Workshop and Conference Held in Kobe, Japan, 10-14 November 1996. Garland Pub., 1998.
- Cognasse, F., HamzehCognasse, H., Lafarge, S., Chavarin, P., Pozzetto, B., Richard, Y., Garraud, O. (2008). Identification of two subpopulations of purified human blood B cells, CD27 CD23+ and CD27high CD80+, that strongly express cell surface Tolllike receptor 9 and secrete high levels of interleukin6.Immunology,125(3), 430-437.
- Bashuda, H., Kimikawa, M., Seino, K., Kato, Y., Ono, F., Shimizu, A., ... Okumura, K. (2005). Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates.Journal of Clinical Investigation,115(7), 1896-1902.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
PE
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
941
NCBI Official Name:
CD80 molecule
NCBI Official Symbol:
CD80
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Innate Immunity,Immunology
SPECIFICITY:
The 2D10.4 antibody reacts with human CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR).
Swissprot #:
P33681
User NOte:
Optimal dilutions for each application to be determined by the researcher.