CD51/CD61 Antibody [23C6]
| Code | Size | Price |
|---|
| PSI-76-174-0.05mg | 0.05mg | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: 23C6
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Functional Study
Storage:
The product should be stored undiluted at 4°C. Do not freeze.
Documents
Further Information
Additional Names:
CD51, MSK8, VNRA, VTNR, GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, ITGAV, ITGB3
Background:
The 23C6 monoclonal antibody specifically reacts with the human CD51/61 molecule, known as the integrin alpha v Beta 3 complex or vitronectin receptor. The complex binds to other ligands such as CD29, fibrinogen, fibrinectin, vWf, laminin, and thrombospondin. It is expressed by endothelial cells, osteoclasts, melanoma cells, and at low levels on platelets and macrophages. The 23C6 antibody is reported to be able to block the receptors ability to form interactions with some of its ligands.
Background References:
- Horton, M. A., Lewis, D., McNulty, K., Pringle, J. A., Chambers, T. J. (1985). Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.Cancer research,45(11 Part 2), 5663-5669.
- Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
- Chuntharapai, A., Bodary, S., Horton, M., Kim, K. J. (1993). Blocking monoclonal antibodies to alpha v-beta 3 integrin: A unique epitope of alpha v-beta 3 integrin is present on human osteoclasts.Experimental cell research,205(2), 345-352.
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
3685; 3690
NCBI Official Name:
integrin, alpha V; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
NCBI Official Symbol:
ITGAV; ITGB3
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/?g of the protein.
Research Area:
Immunology,Functional Assays
SPECIFICITY:
The 23C6 monoclonal antibody specifically reacts with the human CD51/61 molecule, known as the integrin alpha v Beta 3 complex or vitronectin receptor.
Swissprot #:
P06756; P05106
User NOte:
Optimal dilutions for each application to be determined by the researcher.