CD2 Antibody [RPA-2.10]

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ProSci
Product Code: PSI-76-186
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-76-186-0.5mg0.5mg£693.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: Mouse IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: RPA-2.10
Regulatory Status: RUO
Target Species: Human
Applications:
  • Flow Cytometry
  • Functional Study
Storage:
The product should be stored undiluted at 4°C. Do not freeze.

Images

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Human peripheral blood lymphocytes were stained with FITC RPA-2.10 with relevant isotype control in Red.
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Human peripheral blood lymphocytes were stained with FITC RPA-2.10 with relevant isotype control in Red.

Documents

Further Information

Additional Names:
T11, SRBC, LFA-2, CD2
Background:
The RPA-2.10 monoclonal antibody specifically binds to human CD2, a 50 kDA type I transmembrane glycoprotein. CD2 is expressed on NK cells, thymocytes, T lymphocytes, and B cell subsets. CD2 is involved in cell-cell adhesion, T cell activation, and T cell signaling. Its ligand is CD58 and it is reported to bind to CD48, CD59, and CD15. The RPA-2.10 antibody is reported to be cross-reactive with pigs and non-human primates..
Background References:
  • Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
  • Hahn, W. C., Burakoff, S. J., Bierer, B. E. (1993). Signal transduction pathways involved in T cell receptor-induced regulation of CD2 avidity for CD58.The Journal of Immunology,150(7), 2607-2619.
  • Aversa, G. G., Bishop, G. A., Suranyi, M. G., Hall, B. M. (1987, February). RPA-2.10: an anti-CD2 monoclonal antibody that inhibits alloimmune responses and monitors T cell activation. InTransplantation proceedings(Vol. 19, No. 1 Pt 1, pp. 277-278).
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
914
NCBI Official Name:
CD2 molecule
NCBI Official Symbol:
CD2
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/?g of the protein.
Research Area:
Immunology,Functional Assays
SPECIFICITY:
The RPA-2.10 monoclonal antibody specifically binds to human CD2, a 50 kDA type I transmembrane glycoprotein.
Swissprot #:
P06729
User NOte:
Optimal dilutions for each application to be determined by the researcher.