CD28 Antibody [CD28.2]
| Code | Size | Price |
|---|
| PSI-76-727-0.5mg | 0.5mg | £565.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: CD28.2
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Functional Study
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
Storage:
The product should be stored undiluted at 4°C. Do not freeze.
Documents
Further Information
Additional Names:
Tp44, CD28
Background:
The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes. CD28 is a ligand for B7-1 (CD80) and B7-2 (CD86), a co-stimulator of T lymphocytes, and enhances the interaction between T and B lymphocytes. It has been reported that the T lymphocytes stimulation to produce IL-2 depends on the monoclonal antibody involved, which suggests that the CD28 molecule presents some subregions with distinct functions. The CD28.2 antibody induces Ca2+ influx in Jurkat T lymphocytes. Other studies have shown that CD28 is involved in the signal transduction.
Background References:
- Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York
- Nuns, J., Klasen, S., Ragueneau, M., Pavon, C., Couez, D., Mawas, C., ... Olive, D. (1993). CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events.International immunology,5(3), 311-315.
- Karlsson, I., Malleret, B., Brochard, P., Delache, B., Calvo, J., Le Grand, R., Vaslin, B. (2007). FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load.Journal of virology,81(24), 13444-13455.
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
920
NCBI Official Name:
CD28 molecule
NCBI Official Symbol:
CD28
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/?g of the protein.
Research Area:
Immunology,Functional Assays
SPECIFICITY:
The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes.
Swissprot #:
P10747
User NOte:
Optimal dilutions for each application to be determined by the researcher.