PALMD Antibody
| Code | Size | Price |
|---|
| PSI-8237-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-8237-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
PALMD antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Documents
Further Information
Additional Names:
Palmdelphin, C1orf11, FLJ20271, PALML, Paralemnin-like protein
Application Note:
PALMD antibody can be used for detection of PALMD by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
Palmdelphin (PALMD) is a member of the paralemmin families that are lipid-anchored proteins having a role in the cell shape control and cell dynamics (1,2). While Paralemmin proteins typically anchor to the cytoplasm through via palmytoylation and prenylation, PALMD is found predominantly in the cytosol (3). PALMD is targeted to the nucleus to induce apoptosis in response to DNA damage (3-5). Abnormal genetic alterations in PALMD are observed in many malignant tumors (5).
Background References:
- Hultqvist G, Ocampo Daza D, Larhammar D, et al. Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. PLoS One 2012; 7:e41850.
- Andreu N, Escarceller M, Feather S, et al. PALML, a novel paralemmin-related gene mapping on human chromosome 1p21. Gene 2001; 278:33-40.
- Hu B, Copeland NG, Gilbert DJ, et al. The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative. Biochem. Biophys. Res. Commun. 2001; 285:1369-76.
- Dashzeveg N, Taira N, Lu ZG, et al. Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage. Cell Death Dis. 2014; 5:e1221.
Buffer:
PALMD antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (100%), Bovine: (93%), Pig: (93%), Mouse: (86%)
Immunogen:
PALMD antibody was raised against a 15 amino acid peptide near the carboxy terminus of human PALMD.
The immunogen is located within amino acids 460 - 510 of PALMD.
The immunogen is located within amino acids 460 - 510 of PALMD.
NCBI Gene ID #:
54873
NCBI Official Name:
palmdelphin
NCBI Official Symbol:
PALMD
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 61 kDa
Observed: 60 kDa
Observed: 60 kDa
Protein Accession #:
NP_060204
Protein GI Number:
8923243
Purification:
PALMD antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis,Cancer
SPECIFICITY:
PALMD antibody is human specific. At least two isoforms are known to exist.
Swissprot #:
Q9NP74
User NOte:
Optimal dilutions for each application to be determined by the researcher.