KIR2DS2 Antibody
| Code | Size | Price |
|---|
| PSI-8201-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-8201-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
KIR2DS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Documents
Further Information
Additional Names:
Killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 2, KIR2DL3, MHC class I NK cell receptor, Natural killer-associated transcript 5, NKAT5, p58 KIR, p58 natural killer cell receptor clone CL-49, p58 NK receptor
Application Note:
KIR2DS2 antibody can be used for detection of KIR2DS2 by Western blot at 1 - 2 μg/ml. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells (1). The KIR proteins are classified by the number of extracellular immunoglobulin domains and by whether they have a long (L) or short (S) cytoplasmic domain (2,3). KIR proteins are thought to play an important role in regulation of the immune response (3). KIR2DS2 downregulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells and is a receptor on natural killer (NK) cells for HLA-C alleles (3,4).
Background References:
- Colonna M and Samaridis J. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 1995; 268:405-8.
- Biassoni R, Cantoni C, Falco M, et al. The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. J. Exp. Med. 1996; 183:645-50.
- Wagtmann N, Biassoni R, Cantoni C, et al. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity 1995; 2:439-49.
- Moesta AK and Parham P. Diverse functionality among human NK cell receptors for the C1 epitope of HLA-C: KIR2DS2, KIR2DL2, and KIR2DL3. Front. Immunol. 2012; 3:336.
Buffer:
KIR2DS2 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
KIR2DS2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KIR2DS2.
The immunogen is located within the last 50 amino acids of KIR2DS2.
The immunogen is located within the last 50 amino acids of KIR2DS2.
Molecular Weight Explanation:
potentially post-translationally modified
NCBI Gene ID #:
100132285
NCBI Official Name:
Killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 2
NCBI Official Symbol:
KIR2DS2
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 28, 33, 37 kDa
Observed: 34, 42 kDa
Observed: 34, 42 kDa
Protein Accession #:
NP_036444
Protein GI Number:
6912472
Purification:
KIR2DS2 antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
SPECIFICITY:
KIR2DS2 antibody is human specific. Multiple isoforms are known to exist.
Swissprot #:
P43631
User NOte:
Optimal dilutions for each application to be determined by the researcher.