MDM2 (phospho Ser186/Ser188) Antibody
| Code | Size | Price |
|---|
| PSI-79-820-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Immunofluorescence (IF)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
Oncoprotein Mdm2, p53-binding protein Mdm2, Ubiquitin-protein ligase E3 Mdm2
Background:
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues
Background References:
- M Zhou, Blood, Mar 1995; 85: 1608 - 1614.
- Susan M. Mendrysa, Mol. Cell. Biol., Mar 2000; 20: 2023 - 2030.
- M. Saeed Sheikh, Cancer Res., Jul 1993; 53: 3226 - 3228.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MDM2 (phospho Ser186/Ser188) antibody was raised against a peptide sequence around phosphorylation site of Ser186/Ser188 (H-K-S (p)-D-S (p)-I-S) derived from Human MDM2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
4193
NCBI Official Name:
MDM2 oncogene, E3 ubiquitin protein ligase
NCBI Official Symbol:
MDM2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
55 kDa
Protein Accession #:
NP_001138811.1
Protein GI Number:
89993689
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of MDM2 only when phosphorylated at serine 186 and serine 188.
Swissprot #:
Q00987