TOP2A (phospho Thr1343) Antibody
| Code | Size | Price |
|---|
| PSI-79-874-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
TP2A, TOP2, TOP2A, P11388-1
Application Note:
Western Blot: 1:500~1:1000
Background:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event.
Background References:
- Tsai-Pflugfelder M., Proc. Natl. Acad. Sci. U.S.A. 85:7177-7181(1988).
- Wasserman R.A., Cancer Res. 53:3591-3596(1993).
- Lang A.J., Gene 221:255-266(1998).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TOP2A (phospho Thr1343) antibody was raised against a peptide sequence around phosphorylation site of threonine1343 (E-K-T (p)-D-D) derived from Human TOP2A.
Modifications:
Phospho-Specific
NCBI Gene ID #:
7153
NCBI Official Name:
topoisomerase (DNA) II alpha 170kDa
NCBI Official Symbol:
TOP2A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
190 kDa
Protein Accession #:
NP_001058.2
Protein GI Number:
19913406
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of TOP2A only when phosphorylated at threonine 1343.
Swissprot #:
P11388