AIRE (phospho Ser156) Antibody
| Code | Size | Price |
|---|
| PSI-79-892-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
AIRE1, APECED, APS1, APSI, PGA1
Application Note:
Western Blot: 1:500~1:1000
Background:
The function of the protein encoded by this gene is not well defined, however it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described [1]. The longer AIRE-1 mRNA appears to be more abundant and includes exons 1 through 14. Splice variant AIRE-2 includes a portion of the non-coding region of exon 1, an alternatively spliced longer exon 8, plus exons 9 through 14. Variant AIRE-3 includes the same exon 1-8-9 sequences as found in AIRE-2 but utilizes additional alternative splicing in exon 10 that shifts the reading frame such that a stop codon in exon 12 is utilized.
Background References:
- Nagamine K., Nat. Genet. 17:393-398(1997).
- Aaltonen J., Nat. Genet. 17:399-403(1997).
- Hattori M., Nature 405:311-319(2000).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
AIRE (phospho Ser156) antibody was raised against a peptide sequence around phosphorylation site of Serine156 P-G-S (p)-Q-L) derived from Human AIRE.
Modifications:
Phospho-Specific
NCBI Gene ID #:
326
NCBI Official Name:
autoimmune regulator
NCBI Official Symbol:
AIRE
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Protein Accession #:
NP_000374.1
Protein GI Number:
4557291
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of AIRE only when phosphorylated at serine 156.
Swissprot #:
O43918