CDC25B (phospho Ser353) Antibody
| Code | Size | Price |
|---|
| PSI-79-999-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
CDC25M2, MPIP2, Dual specificity phosphatase Cdc25B, CDC25HU2,
Application Note:
Western Blot: 1:500~1:1000
Background:
Cdc25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.
Background References:
- Reboutier D, et al. (2012) J Cell Biol 197, 19-26
- Lobjois V, et al. (2011) Biochem Biophys Res Commun 410, 87-90
- Feng C, et al. (2007) Biol Reprod 77, 560-8
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CDC25B (phospho Ser353) antibody was raised against a peptide sequence around phosphorylation site of serine 353 (R-R-S (p)-V-T) derived from Human CDC25B .
Modifications:
Phospho-Specific
NCBI Gene ID #:
994
NCBI Official Name:
cell division cycle 25B
NCBI Official Symbol:
CDC25B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
64 kDa
Protein Accession #:
NP_001274445.1
Protein GI Number:
11641413
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of CDC25B only when phosphorylated at serine 353.
Swissprot #:
P30305