CD62P Antibody [Psel.KO2.3] (PE)
| Code | Size | Price |
|---|
| PSI-76-209-0.1mg | 0.1mg | £505.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: Psel.KO2.3
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Flow Cytometry
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Documents
Further Information
Additional Names:
CD62, GRMP, PSEL, CD62P, GMP140, LECAM3, PADGEM, Lnhr, CD62L, Ly-22, Lyam1, Ly-m22, Lyam-1, LECAM-1, AI528707, L-selectin, SELP
Background:
The Psel.KO2.3 monoclonal antibody specifically reacts with mouse CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as granule membrane protein 140 (GMP-140). Upon activation it is quickly transported to the plasma membrane from the alpha-granules of platelets and WEibel-Palade bodies of endothelial cells. It is essential to the functions of cell adhesion during inflammatory reactions and in the interaction of platelets with monocytes and neutrophils. The Psel.KO2.3 antibody does not block adhesion and binds to an epitope common to several species including mouse, human, and rat.
Background References:
- Massaguer, A., Engel, P., PrezdelPulgar, S., Bosch, J., Pizcueta, P. (2000). Production and characterization of monoclonal antibodies against conserved epitopes of Pselectin (CD62P).Tissue antigens,56(2), 117-128.
- Kansas, G. S. (1996). Selectins and their ligands: current concepts and controversies.Blood,88(9), 3259-3287.
- Bullard, D. C., Kunkel, E. J., Kubo, H., Hicks, M. J., Lorenzo, I., Doyle, N. A., ... Beaudet, A. L. (1996). Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice.The Journal of experimental medicine,183(5), 2329-2336.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
PE
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
6403; 20344
NCBI Official Name:
selectin P (granule membrane protein 140kDa, antigen CD62)
NCBI Official Symbol:
SELP
NCBI Organism:
Homo sapiens; Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Immunology
SPECIFICITY:
The Psel.KO2.3 monoclonal antibody specifically reacts with mouse CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as granule membrane protein 140 (GMP-140).
Swissprot #:
P16109; P18337
User NOte:
Optimal dilutions for each application to be determined by the researcher.