CD44 Antibody [IM7] (Violet-450)
| Code | Size | Price |
|---|
| PSI-76-412-0.1mg | 0.1mg | £433.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: Rat IgG2b, kappa
Antibody Clonality: Monoclonal
Antibody Clone: IM7
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Flow Cytometry
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Documents
Further Information
Additional Names:
IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CDW44, CSPG8, HCELL, HUTCH-I, ECMR-III, Ly-24, Pgp-1, HERMES, AU023126, AW121933, AW146109, CD44
Background:
The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24). CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice. The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Background References:
- Trowbridge, I. S., Lesley, J., Schulte, R., Hyman, R., Trotter, J. (1982). Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues.Immunogenetics,15(3), 299-312.
- Lesley, J., Trowbridge, I. S. (1982). Genetic characterization of a polymorphic murine cell-surface glycoprotein.Immunogenetics,15(3), 313-320.
- Nedvetzki, S., Walmsley, M., Alpert, E., Williams, R. O., Feldmann, M., Naor, D. (1999). CD44 involvement in experimental collagen-induced arthritis (CIA).Journal of autoimmunity,13(1), 39-47.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
Violet-450
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
960; 12505
NCBI Official Name:
CD44 molecule (Indian blood group)
NCBI Official Symbol:
CD44
NCBI Organism:
Homo sapiens; Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Immunology,Stem Cell
SPECIFICITY:
The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24).
Swissprot #:
P16070; P15379
User NOte:
Optimal dilutions for each application to be determined by the researcher.