LATS1/2 (phospho Thr1079/1041) Antibody
| Code | Size | Price |
|---|
| PSI-79-850-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Immunohistochemistry (IHC)
Storage:
Store antibody at -20˚,C for up to one year.
Documents
Further Information
Additional Names:
WARTS, Large tumor suppressor 1, EC 2.7.11.1
Background:
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding.
Background References:
- Tao W., Nat. Genet. 21:177-181(1999).
- Nishiyama Y., FEBS Lett. 459:159-165(1999).
- The MGC Project Team, Genome Res. 14:2121-2127(2004).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
LATS1/2 (phospho Thr1079/1041) antibody was raised against a peptide sequence around phosphorylation site of threonine 1079/1041 (E-F-T (p)-F-R) derived from Human LATS1/2 .
Modifications:
Phospho-Specific
NCBI Gene ID #:
9113/26524
NCBI Official Name:
large tumor suppressor kinase 1, large tumor suppressor kinase 2
NCBI Official Symbol:
LATS1, LATS2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
126 kDa
Protein Accession #:
NP_004681.1
Protein GI Number:
4758666
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of LATS1/2 only when phosphorylated at threonine 1079/1041.
Swissprot #:
O95835/Q9NRM7