MLK1/2 (phospho Thr312/266) Antibody
| Code | Size | Price |
|---|
| PSI-79-857-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Immunohistochemistry (IHC)
Storage:
Store antibody at -20˚,C for up to one year.
Documents
Further Information
Additional Names:
M3K9, PRKE1, mixed-lineage protein kinase 1
Background:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
Background References:
- Durkin J.T., Biochemistry 43:16348-16355(2004).
- The MGC Project Team, Genome Res. 14:2121-2127(2004).
- Dorow D.S.,Nature 446:153-158(2007).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MLK1/2 (phospho Thr312/266) antibody was raised against a peptide sequence around phosphorylation site of threonine 312/266 (A-G-T (p)-Y-A) derived from Human MLK1/2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
4293/4294
NCBI Official Name:
mitogen-activated protein kinase kinase kinase 9, mitogen-activated protein kinase kinase kinase 10
NCBI Official Symbol:
MAP3K9, MAP3K10
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
121 kDa
Protein Accession #:
NP_001271159.1
Protein GI Number:
52421790
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of MLK1/2 only when phosphorylated at threonine 312/266.
Swissprot #:
P80192/Q02779