PEK/PERK (phospho Thr981) Antibody
| Code | Size | Price |
|---|
| PSI-79-862-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Immunohistochemistry (IHC)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
E2AK3, PERK, PEK, EIF2AK3
Background:
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1)
Background References:
- Shi Y., An J., J. Biol. Chem. 274:5723-5730(1999).
- Sood R., Biochem. J. 346:281-293(2000).
- The MGC Project Team; Genome Res. 14:2121-2127(2004).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PEK/PERK (phospho Thr981) antibody was raised against a peptide sequence around phosphorylation site of threonine 981 (A-R-H (p)-T-G) derived from Human PEK/PERK.
Modifications:
Phospho-Specific
NCBI Gene ID #:
9451
NCBI Official Name:
eukaryotic translation initiation factor 2-alpha kinase 3
NCBI Official Symbol:
EIF2AK3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
125 kDa
Protein Accession #:
NP_004827.4
Protein GI Number:
296439367
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of PEK/PERK only when phosphorylated at threonine 981.
Swissprot #:
Q9NZJ5